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CagriSema RxGet started
Compounded semaglutide with vitamin B12 vial on a stone plinth
Form
Weekly injection
Formula
Semaglutide + B12
Dose
Set by your provider
Plans
1 to 12 months

RxMedical weight loss

Semaglutide

Prescribed online. Made by a licensed 503A pharmacy.

CagriSema pairs cagrilintide with semaglutide, and it is not sold here. This plan is weekly compounded semaglutide with vitamin B12, with no cagrilintide. A licensed provider reviews your order, then a licensed 503A pharmacy ships it cold, with injection supplies included.

  • Weekly injection
  • Semaglutide + B12
  • No cagrilintide
  • Provider reviewed
  • First month $99
What's included
  • Provider review. A licensed provider reads your health intake and decides if semaglutide is right for you.
  • Your medication. Semaglutide with vitamin B12, compounded by a licensed 503A pharmacy at the dose you're prescribed.
  • Injection supplies. Injection supplies come with every order, at no extra cost.
  • Cold-chain shipping. Packed cold and shipped to your door in plain packaging, at no added cost.
  • One price at any dose. The price is the same at every dose, so a dose change never costs more.
  • Refund if not prescribed. If the provider does not prescribe, your charge is refunded.

Choose your plan

3-month plan$365
  • $365 billed today$399
  • Covers your first 3 months
  • Refunded if the provider does not prescribe
  • Licensed provider review
  • Supplies and shipping included
  • No membership fee

Each plan is a one-time charge for its length; Subscribe & Save is optional at the next step. Prescription treatment requires an online medical evaluation. A provider decides whether treatment is appropriate; approval is not guaranteed.

Order today. Here's what happens next.

  1. 1TodayChoose your plan and pay securely in a couple of minutes.
  2. 2Provider reviewA licensed provider reviews your intake. If you're not prescribed, you're refunded.
  3. 3At your doorShipped cold in plain packaging, with injection supplies included.
Licensed providersEvery order is reviewed by a licensed provider before it ships.
503A pharmacyCompounded for you by a state-licensed 503A pharmacy.
Cold-chain shippingPacked cold in plain packaging, at no extra cost.
Refund if not prescribedIf the provider does not prescribe, your charge is refunded.

Common questions

Do you sell CagriSema?

No. CagriSema combines cagrilintide and semaglutide, and FDA says cagrilintide cannot be used in compounding. We sell compounded semaglutide, one of CagriSema's two ingredients, as a weekly injection with vitamin B12. It contains no cagrilintide.

How much does semaglutide cost?

Your first month is $99, then $190 a month. A 3-month plan is $399, or $365 for your first one ($121.67 a month). Your first 6 months are $694 ($115.67 a month) and your first 12 months are $1,188 ($99 a month). Injection supplies and shipping are included. Lab work is not.

What if I'm not prescribed?

A licensed provider reviews every order before anything ships, and approval is not guaranteed. If the provider does not prescribe, your charge is refunded.

Is compounded semaglutide the same as Wegovy or Ozempic?

No. Compounded semaglutide is not FDA approved and is not interchangeable with Wegovy or Ozempic. A licensed provider decides whether it is right for you.

All questions
Licensed 503A pharmacyPrepares every orderIndependent providersUS-licensed reviewFree discreet shippingPlain packagingCancel anytimeNo long contractsHIPAA-compliantYour data stays privateLicensed 503A pharmacyPrepares every orderIndependent providersUS-licensed reviewFree discreet shippingPlain packagingCancel anytimeNo long contractsHIPAA-compliantYour data stays private
A woman in her 50s walking a golden retriever along a misty pine forest trail

Clearly named

Semaglutide, on its own and clearly labeled.

CagriSema adds cagrilintide, which FDA says cannot be used in compounding. Your plan is weekly semaglutide with B12, with a licensed provider behind every order and one price at every dose.

  • 01Licensed 503A pharmacy
  • 02Once a week
  • 03Provider reviewed
  • 04Ships cold
Choose a plan

Why us

Why CagriSema Rx

Semaglutide vial on a bathroom counter

Made for you by a licensed pharmacy

Compounded with vitamin B12 by a licensed 503A pharmacy, at the dose your provider prescribes.

Close-up of the semaglutide label

Named for what's inside

Semaglutide with vitamin B12. No cagrilintide, and never sold as CagriSema.

A woman repotting herbs on a sunny patio

A provider in your corner

A licensed provider reviews your intake before anything ships, with no office visit.

Semaglutide vial in a plain shipping box

Start for $99

Your first month is $99, and the price stays the same at every dose. Supplies and shipping included.

14.9%Average weight loss on weekly semaglutide 2.4 mgSTEP 1 · 1,961 adults · 68 weeks2.4%Average weight loss on placeboSTEP 1 · 1,961 adults · 68 weeks6.5% vs 8.0%Major cardiovascular events, semaglutide vs placeboSELECT · 17,604 adults · mean 39.8 months

Results from trials of brand-name weekly semaglutide 2.4 mg with lifestyle support. They are not results for compounded semaglutide or for any one person. Individual results vary.

How we compare

Semaglutide, clearly sourced.

FeatureCagriSema RxBrand-name pens at retailIn-person clinic
Licensed provider review included×
Made by a licensed pharmacyn/aVaries
No office visitVaries×
Price shown before you payVariesVaries
Injection supplies includedVariesVaries
Choose a plan
Semaglutide vial in a plain shipping box

How it works

A straightforward path to care

  1. 1

    Choose your plan

    Start with one month of semaglutide for $99, or pick a 3, 6 or 12-month plan.

  2. 2

    Complete your health intake

    Answer a private online questionnaire. A licensed provider reviews it. If you're not prescribed, you're refunded.

  3. 3

    Get it delivered

    If prescribed, your semaglutide and injection supplies ship cold to your door.

Get started

About semaglutide

Semaglutide is one of CagriSema's two ingredients. The other, cagrilintide, cannot be used in compounding, according to FDA. Your plan is compounded semaglutide with vitamin B12, taken as a weekly injection and dosed by your provider.

  • One of CagriSema's two ingredients
  • Tested alone as one arm of REDEFINE 1
  • No cagrilintide in your vial
  • Your vial: semaglutide + B12, provider-set dose
FDA on unapproved GLP-1 drugs
  1. CagriSemaCagrilintide plus semaglutide, tested in the REDEFINE trials
  2. CagrilintideCannot be used in compounding and is not part of any FDA-approved drug
  3. Your vialSemaglutide with B12, compounded by a licensed 503A pharmacy after provider review

Prepared for you by a licensed pharmacy, after a provider review.

Why people choose it

What CagriSema is studied for

Each card links to the original study, with a tag for the kind of evidence behind it.

Controlled human trial

Weight loss without diabetes

In REDEFINE 1, adults with overweight or obesity and no diabetes lost an average of 20.4% of body weight on CagriSema over 68 weeks, versus 3.0% on placebo.

Read the study Controlled human trial

Weight loss with type 2 diabetes

In REDEFINE 2, 1,206 adults with type 2 diabetes and a BMI of 27 or more lost an average of 13.7% on CagriSema at 68 weeks, versus 3.4% on placebo.

Read the study Controlled human trial

Each ingredient tested alone

REDEFINE 1 randomized 3,417 adults to CagriSema, cagrilintide alone, semaglutide alone or placebo, all with lifestyle support.

Read the study

The honest version

What the CagriSema trials do and don't tell you

CagriSema has two large trials behind it. Here is what they mean for someone choosing semaglutide today.

See every study we track

  • FDA says cagrilintide cannot be used in compounding and is not part of any FDA-approved drug. CagriSema is not sold here.

    Source

  • Stomach side effects were common in REDEFINE 1: 79.6% on CagriSema versus 39.9% on placebo.

    Source

  • Both REDEFINE trials were funded by Novo Nordisk and tested the trial combination, not compounded products. Their results do not apply to compounded semaglutide.

    Source

Shop CagriSema Rx

Weekly GLP-1 plans

CagriSema is not sold here. Both plans below are reviewed by a licensed provider and shipped free from a licensed pharmacy.

Weekly injection

Compounded semaglutide

Weekly injection · first month $99 · semaglutide with B12, no cagrilintide

$99 first month

Weekly injection

Compounded tirzepatide

Weekly injection · first month $149 · contains no cagrilintide

$149 first month

Free resources

Tools to compare your options

Free, with no sign-up.

Compare product forms

Compare the exact ingredient, route and formulation side by side.

Read a study

A plain worksheet for checking what any trial actually tested.

Decision pack

Your questions, a source checklist and a notes log, ready to print.

Research library

Read before you decide

All 12 guides
Research Guides

Would CagriSema evidence change your treatment discussion?

Use comparator, endpoint, added benefit and remaining uncertainty to prepare a precise conversation about combination research.

Research Guides

CagriSema with type 2 diabetes: which trial answers which question?

Distinguish REDEFINE 2, REIMAGINE 2 and the earlier phase 2 study when weighing glucose and weight outcomes.

FAQ

Questions, answered

The things people ask most before starting Semaglutide.

Do you sell CagriSema?

No. CagriSema combines cagrilintide and semaglutide, and FDA says cagrilintide cannot be used in compounding. We sell compounded semaglutide, one of CagriSema's two ingredients, as a weekly injection with vitamin B12. It contains no cagrilintide.

How much does semaglutide cost?

Your first month is $99, then $190 a month. A 3-month plan is $399, or $365 for your first one ($121.67 a month). Your first 6 months are $694 ($115.67 a month) and your first 12 months are $1,188 ($99 a month). Injection supplies and shipping are included. Lab work is not.

What if I'm not prescribed?

A licensed provider reviews every order before anything ships, and approval is not guaranteed. If the provider does not prescribe, your charge is refunded.

Is compounded semaglutide the same as Wegovy or Ozempic?

No. Compounded semaglutide is not FDA approved and is not interchangeable with Wegovy or Ozempic. A licensed provider decides whether it is right for you.

What did the CagriSema trials find?

In REDEFINE 1, adults without diabetes lost an average of 20.4% of body weight on CagriSema over 68 weeks, versus 3.0% on placebo. In REDEFINE 2, adults with type 2 diabetes lost 13.7% versus 3.4%. Stomach side effects were common in both.

Will semaglutide alone match those results?

No one can promise that. The REDEFINE results above are for the cagrilintide and semaglutide combination. They do not apply to semaglutide alone or to compounded semaglutide.

Does the price go up when my dose goes up?

No. The price is the same at every dose. Your provider sets your dose and when it changes.

Does my plan renew automatically?

No. Each plan is a one-time charge for its length. Subscribe & Save is optional and renews $25 below the plan price.

Start semaglutide for $99.

First month $99. Injection supplies and shipping included. Refunded if not prescribed.

Choose your plan